Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0215 | - |
4-methyl-2-oxopentanoate | - |
Rattus norvegicus | |
0.0219 | - |
3-methyl-2-oxopentanoate | - |
Rattus norvegicus | |
0.0372 | - |
3-methyl-2-oxobutanoate | - |
Rattus norvegicus | |
0.97 | - |
pyruvate | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38500 | - |
alphax,betax, x * 46500 + x * 38500, SDS-PAGE | Rattus norvegicus |
46500 | - |
alphax,betax, x * 46500 + x * 38500, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
hydrophobic interaction chromatography on phenyl-Sepharose | Rattus norvegicus |
multienzyme complex | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
7.46 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 | - |
? | |
3-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine | - |
Rattus norvegicus | [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 | - |
? | |
4-methyl-2-oxopentanoate + NAD+ + CoA | - |
Rattus norvegicus | 3-methylbutanoyl-CoA + CO2 + NADH | - |
? | |
pyruvate + NAD+ + CoA | - |
Rattus norvegicus | acetyl-CoA + CO2 + NADH | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | alphax,betax, x * 46500 + x * 38500, SDS-PAGE | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
CoA | - |
Rattus norvegicus | |
NAD+ | - |
Rattus norvegicus |