Literature summary for 1.2.4.4 extracted from

Shiraki, M.; Shimomura, Y.; Miwa, Y.; Fukushima, H.; Murakami, T.; Tamura, T.; Tamura, N.; Moriwaki, H.
Activation of hepatic branched-chain alpha-keto acid dehydrogenase complex by tumor necrosis factor-alpha in rats (2005), Biochem. Biophys. Res. Commun., 328, 973-978.

Search for more literature for 1.2.4.4

Activating Compound

Activating Compound	Comment	Organism	Structure
tumor necrosis factor-alpha	activates the multienzyme complex about 4fold at 0.05 mg/kg body weight 4 h prior to slaughtering, reduces the amount of phosphorylated E1b component	Rattus norvegicus
tumor necrosis factor-alpha	0.025 or 0.5 mg per kg body weight elevate the activity state of BCKDH complex from 22% to 69% and 86%, respectively, decrease in the bound form of BCKDH kinase is involved in the mechanism responsible for tumor necrosis factor-alpha induced activation of the BCKDH complex	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	enzyme regulates the catabolism of branched-chain amino acids, and is regulated by phosphorylation-dephosphorylation	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-
Rattus norvegicus	-	female Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme regulates the catabolism of branched-chain amino acids, and is regulated by phosphorylation-dephosphorylation	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
BCKDH	-	Rattus norvegicus
branched-chain alpha-keto acid dehydrogenase complex	-	Rattus norvegicus

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Release 2023.1 (January 2023)