Literature summary for 1.2.99.7 extracted from

Santos-Silva, T.; Ferroni, F.; Thapper, A.; Marangon, J.; Gonzalez, P.J.; Rizzi, A.C.; Moura, I.; Moura, J.J.; Romao, M.J.; Brondino, C.D.
Kinetic, structural, and EPR studies reveal that aldehyde oxidoreductase from Desulfovibrio gigas does not need a sulfido ligand for catalysis and give evidence for a direct Mo-C interaction in a biological system (2009), J. Am. Chem. Soc., 131, 7990-7998.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion method, using 30% (v/v) 2-propanol, 0.2 M magnesium chloride, and 0.2 M HEPES buffer (pH 7.6)	Megalodesulfovibrio gigas

Inhibitors

Inhibitors	Comment	Organism	Structure
arsenite	irreversible inhibitor, complete inhibition at 0.024 mM	Megalodesulfovibrio gigas
cyanide	competitive reversible inhibitor, 30.9% inhibition at 50 mM	Megalodesulfovibrio gigas
ethylene glycol	mixed-type reversible inhibitor, 21.9% inhibition at 1 mM	Megalodesulfovibrio gigas
glycerol	competitive reversible inhibitor, 52% inhibition at 1 mM	Megalodesulfovibrio gigas

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0097	-	benzaldehyde	in 50 mM Tris-HCl buffer (pH 7.6), at 37°C	Megalodesulfovibrio gigas

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Molybdenum	contains molybdenum	Megalodesulfovibrio gigas

Organism

Organism	UniProt	Comment	Textmining
Megalodesulfovibrio gigas	Q46509	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Megalodesulfovibrio gigas

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzaldehyde + H2O + 2,6-dichlorophenolindophenol	-	Megalodesulfovibrio gigas	benzoate + reduced 2,6-dichlorophenol-indophenol	-	?

Synonyms

Synonyms	Comment	Organism
aldehyde oxidoreductase	-	Megalodesulfovibrio gigas
AOR	-	Megalodesulfovibrio gigas

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
1.12	-	benzaldehyde	in 50 mM Tris-HCl buffer (pH 7.6), at 37°C	Megalodesulfovibrio gigas

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Release 2023.1 (January 2023)