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Literature summary for 1.21.1.1 extracted from

  • Sun, X.; Zhang, X.; Jiang, Y.; Bao, S.; Shan, Z.; Teng, W.
    Expression of iodotyrosine deiodinase in thyroid and other organs in iodine-deficient and iodine-excess rats (2015), Biol. Trace Elem. Res., 167, 272-279.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
quantitative RT-PCR enzyme expression analysis, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + 2 NADP+ + 2 iodide Rattus norvegicus
-
3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
r
L-tyrosine + 2 NADP+ + 2 iodide Rattus norvegicus Wistar
-
3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
female
-
Rattus norvegicus Wistar
-
female
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
additional information tissue expression analysis of the enzyme in conditions such as iodine deficiency and excess, overview Rattus norvegicus
-
thyroid
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 2 NADP+ + 2 iodide
-
Rattus norvegicus 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
r
L-tyrosine + 2 NADP+ + 2 iodide
-
Rattus norvegicus Wistar 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H+
-
r

Synonyms

Synonyms Comment Organism
IYD
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
flavin a flavin mononucleotide-dependent deiodinase Rattus norvegicus
NADPH dependent on Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the enzyme is suppressed in liver and kidney by iodine intake. Excess iodine decreases the expression of thyroidal enzyme down
Rattus norvegicus iodine deficiency results in an increased enzyme expression in thyroid up

General Information

General Information Comment Organism
physiological function the enzyme, catalyzing the reductive dehalogenation, is a critical enzyme in maintaining iodine homeostasis Rattus norvegicus