Activating Compound | Comment | Organism | Structure |
---|---|---|---|
O2 | required | Aspergillus nidulans |
Crystallization (Comment) | Organism |
---|---|
enzyme complexed with manganese instead of iron in the active site, more stable | Aspergillus nidulans |
structure analysis | Aspergillus nidulans |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Aspergillus nidulans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 | Aspergillus nidulans | common step in the biosynthesis of penicillins, cephalosporins and cephamycins | isopenicillin N + 2 H2O | product has antibiotic activity | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus nidulans | P05326 | accession number SwissProt | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O | structure and mechanism | Aspergillus nidulans | |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = isopenicillin N + 2 H2O | active site with conserved jelly-roll motif, cysteine residues are not directly involved in the coordination of the metal ion | Aspergillus nidulans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 | - |
Aspergillus nidulans | isopenicillin N + 2 H2O | - |
? | |
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 | common step in the biosynthesis of penicillins, cephalosporins and cephamycins | Aspergillus nidulans | isopenicillin N + 2 H2O | product has antibiotic activity | ? |
Synonyms | Comment | Organism |
---|---|---|
IPNS | - |
Aspergillus nidulans |