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Literature summary for 1.21.3.7 extracted from

  • Shoyama, Y.; Tamada, T.; Kurihara, K.; Takeuchi, A.; Taura, F.; Arai, S.; Blaber, M.; Shoyama, Y.; Morimoto, S.; Kuroki, R.
    Structure and function of DELTA1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa (2012), J. Mol. Biol., 423, 96-105.
    View publication on PubMed
Search for more literature for 1.21.3.7

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Cannabis sativa

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Cannabis sativa

Protein Variants

Protein Variants Comment Organism
E442Q the enzyme shows 85% of wild type activity Cannabis sativa
H114A the mutation completely abolishes enzymatic activity Cannabis sativa
H292A the enzyme shows 5% of wild type activity Cannabis sativa
Y417F the enzyme shows 42% of wild type activity Cannabis sativa
Y484F the mutation completely abolishes enzymatic activity Cannabis sativa

Organism

Organism UniProt Comment Textmining
Cannabis sativa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Cannabis sativa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cannabigerolate + O2
-
 Cannabis sativa DELTA9-tetrahydrocannabinolate + H2O2
-
 ?

Subunits

Subunits Comment Organism
monomer
-
 Cannabis sativa

Synonyms

Synonyms Comment Organism
DELTA1-tetrahydrocannabinolic acid synthase
-
 Cannabis sativa
THCA synthase
-
 Cannabis sativa

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Cannabis sativa

General Information

General Information Comment Organism
physiological function a key enzyme controlling the psychoactivity of cannabis Cannabis sativa