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Literature summary for 1.21.99.3 extracted from

  • Mori, K.; Yoshida, K.; Fukazawa, H.; Kiso, Y.; Sayama, N.; Kikuchi, K.; Aizawa, Y.; Abe, K.
    Thyroid hormone regulates rat placental type III iodothyronine deiodinase activity by inducing kinetic changes different from those in the same isozyme in rat brain (1995), Endocr. J., 42, 753-760.
    View publication on PubMed
Search for more literature for 1.21.99.3

Activating Compound

Activating Compound Comment Organism Structure
Phospholipids no influence on the kinetic parameters of 5-deiodinase activity of isozyme type III in placenta, but essential for activity Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Phospholipids no inhibition of placental isozyme type III Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics, isozyme type III Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome isozyme type III Rattus norvegicus
-
-
mitochondrion isozyme type III Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-
Rattus norvegicus
-
 isozyme type III
-

Source Tissue

Source Tissue Comment Organism Textmining
brain isozyme type III Rattus norvegicus
-
cerebral cortex isozyme type III Rattus norvegicus
-
placenta isozyme type III Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity in hyperthyroid and control rats at different substrate concentrations Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,3',5-triiodo-L-thyronine + AH2 best substrate Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
3,3',5-triiodo-L-thyronine + AH2 isozyme type III Rattus norvegicus 3,3'-diiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 preferred substrate Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 isozyme type III Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
L-thyroxine + AH2 5-deiodinase activity Rattus norvegicus 3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
 ?
additional information placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus