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Literature summary for 1.21.99.3 extracted from

  • Heijlen, M.; Houbrechts, A.M.; Bagci, E.; Van Herck, S.L.; Kersseboom, S.; Esguerra, C.V.; Blust, R.; Visser, T.J.; Knapen, D.; Darras, V.M.
    Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish (2014), Endocrinology, 155, 1547-1559.
    View publication on PubMed
Search for more literature for 1.21.99.3

Organism

Organism UniProt Comment Textmining
Danio rerio
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Danio rerio A0A3G0ZGD9 isoform Dio3a
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Source Tissue

Source Tissue Comment Organism Textmining
additional information both isoforms Dio3a and Dio3b are expressed during development and both contribute to in vivo type 3 iodothyronine deiodinase activity Danio rerio
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Synonyms

Synonyms Comment Organism
Dio3a
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 Danio rerio
Dio3b
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 Danio rerio

General Information

General Information Comment Organism
physiological function mRNA knock-down induces an overall delay in development and a severe delay of the time of hatching. There is a severe disturbance of several aspects of development. Swim bladder development and inflation are aberrant as is the development of liver and intestine. Enzyme knock-down larvae spend significantly less time moving, and both embryos and larvae exhibit perturbed escape responses. Isoform Dio3b mRNA levels in embryos are higher and the effects of Dio3b knock-down on enzymic activity and on the resulting phenotype are more severe than those of Dio2a knock-down Danio rerio
physiological function mRNA knock-down induces an overall delay in development and a severe delay of the time of hatching.There is a severe disturbance of several aspects of development. Swim bladder development and inflation are aberrant as is the development of liver and intestine. Enzyme knock-down larvae spend significantly less time moving, and both embryos and larvae exhibit perturbed escape responses. Isoform Dio3b mRNA levels in embryos are higher and the effects of Dio3b knock-down on enzymic activity and on the resulting phenotype are more severe than those of Dio2a knock-down Danio rerio