General Stability | Organism |
---|---|
activity mostly lost during purification procedures, catalytic activity lost in detergent solution | Rattus sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-bromoacetyl-L-thyroxine | i.e. BrAc-3,3',5-triiodothyronine, all isoenzymes | Rattus sp. |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | isoenzyme type I and type II are both integral membrane proteins | Rattus sp. | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55400 | - |
type I, sucrose density gradient centrifugation and gel filtration | Rattus sp. |
198700 | - |
type II, sucrose density gradient centrifugation and gel filtration | Rattus sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | Rattus sp. | isoenzyme type I | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus sp. | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
no glycoprotein | no glycosylation of substrate binding subunits of both isoenzymes | Rattus sp. |
Purification (Comment) | Organism |
---|---|
isoenzyme type I and type II | Rattus sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glial cell | - |
Rattus sp. | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | isoenzyme type I | Rattus sp. | 3,3'-diiodothyronine + iodide + A + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | substrate binding subunit of multimeric isoenzyme type I has 27 kD and of multimeric isoenzyme type II 29 kD, SDS-PAGE | Rattus sp. |
Synonyms | Comment | Organism |
---|---|---|
iodothyronine 5'-deiodinase | isoenzymes type I (D1) and type II (D2) | Rattus sp. |