Protein Variants | Comment | Organism |
---|---|---|
SeC133A | inactive mutant enzyme | Homo sapiens |
SeC133C | the Km-value for L-thyroxine is 1500fold higher than the wild-type value, the turnover-number is 10fold lower than the wild-type value | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000014 | - |
L-thyroxine | wild-type enzyme | Homo sapiens | |
0.0021 | - |
L-thyroxine | mutant enzyme SeC133C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Se | enzyme contains selenocysteine in the highly conserved active senter at position 133. Selenium plays a critical role in deiodination | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92813 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | - |
Homo sapiens | 3,3',5-triiodothyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
type 2 iodothyronine deiodinase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |