Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | Mus musculus | - |
3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
myocardium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-thyroxine + AH2 | - |
Mus musculus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DIO2 | - |
Mus musculus |
type 2 iodothyronine deiodinase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | type 2 iodothyronine deiodinase (Dio2) is up-regulated in dilated cardiomyopathy mice hearts whereas the expression of type 1 iodothyronine deiodinase remains unchanged. Dio2 gene expression is also markedly up-regulated in the mice hearts developing similar eccentric hypertrophy after myocardial infarction | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Dio2 up-regulation is involved in cardiac remodelling in dilated cardiomyopathy through activating the thyroid hormone-signalling pathways involving Akt and p38 MAPK | Mus musculus |