Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | Mus musculus | - |
3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | Mus musculus | - |
3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
muscle progenitor cell | high expression | Mus musculus | - |
myoblast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5'-triiodothyronine + AH2 | - |
Mus musculus | 3,3'-diiodothyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | - |
Mus musculus | 3,5,3'-triiodo-L-thyronine + iodide + A + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DIO2 | - |
Mus musculus |
type 2 deiodinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | type 2 deiodinase is induced in muscle regeneration, forkhead box O3 is a key molecule inducing type 2 deiodinase expression | up |
General Information | Comment | Organism |
---|---|---|
malfunction | after injury regeneration markedly delays in muscles of mice null for the gene encoding type 2 deiodinase, despite normal circulating 3,5,3'-triiodo-L-thyronine concentrations, Dio2-deficient mice show muscle-specific hypothyroidism | Mus musculus |
physiological function | type 2 deiodinase is essential for normal mouse myogenesis and muscle regeneration | Mus musculus |