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Literature summary for 1.21.99.4 extracted from

  • Lamirand, A.; Ramauge, M.; Pierre, M.; Courtin, F.
    Bacterial lipopolysaccharide induces type 2 deiodinase in cultured rat astrocytes (2012), J. Endocrinol., 208, 183-192.
    View publication on PubMed
Search for more literature for 1.21.99.4

Inhibitors

Inhibitors Comment Organism Structure
additional information lipopolysaccharide-induced type 2 deiodinase activity is not inhibited by 1 mM 6-propyl-2-thiouracil Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000001
-
 L-thyroxine pH and temperature not specified in the publication Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-thyroxine + AH2
-
 Rattus norvegicus 3,5,3'-triiodo-L-thyronine + iodide + A + H+
-
 ?

Synonyms

Synonyms Comment Organism
type 2 deiodinase
-
 Rattus norvegicus
type 2 iodothyronine deiodinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus bacterial lipopolysaccharide induces type 2 iodothyronine deiodinase (D2) activity with a lag-time of 4-8 h and a maximum at 24 h at 0.001 mg /ml. Glucocorticoids (0.001 mM cortisol, 10 nM dexamethasone) enhance both the basal and LPS-stimulated D2 activity and mRNA accumulation. RU486 and sulfasalazine block the effects of lipopolysaccharide on both D2 activity and mRNA accumulation. In astrocytes, co-expression of p65 nuclear factor-kappaB with the 3.8 kb form of the rat dio2 promoter leads to a 7fold increase in the transcriptional activity up

General Information

General Information Comment Organism
physiological function brain D2 is implicated in adaptative responses to infectious stress Rattus norvegicus