Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation IVS14+1G>A results in a 165bp deletion (corresponding to exon 14) in the DPD mRNA, the resulting protein product is truncated by 55 amino acids, and its catalytic activity is virtually absent, the mutation is responsible for a significant proportion of life-threatening toxicity of 5-fluorouracil | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + NADH + H+ | dihydropyrimidine dehydrogenase is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil | Homo sapiens | 5-fluoro-5,6-dihydrouracil + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dihydropyrimidine dehydrogenase | - |
Homo sapiens |
DPD | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |