Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.10 extracted from

  • Heath, R.J.; Rock, C.O.
    A triclosan-resistant bacterial enzyme (2000), Nature, 406, 145-146.
    View publication on PubMed
Search for more literature for 1.3.1.10

Cloned(Commentary)

Cloned (Comment) Organism
fabK in expression plasmid Streptococcus pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by: triclosan Streptococcus pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 FabK, gene sequence Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Streptococcus pneumoniae part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.066
-
-
 Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-[acyl-carrier protein] + NADPH substrate created by E. coli enzymes during assay Streptococcus pneumoniae butyryl-[acyl-carrier protein] + NADP+
-
 ?
additional information part of fatty acid synthesis reducing double bonds of a great varity of acyl thioesters Streptococcus pneumoniae ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
FAD enzyme contains 0.8 mol FAD/enzyme, but functional role is not investigated Streptococcus pneumoniae
NADH also essential for activity, article leaves doubtful whether NADH or NADPH or both are cofactors Streptococcus pneumoniae