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Literature summary for 1.3.1.10 extracted from
- Aquastatin A, a new inhibitor of enoyl-acyl carrier protein reductase from Sporothrix sp. FN611 (2009), Biol. Pharm. Bull., 32, 2061-2064.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the bacterial enoyl-ACP reductase is a target for antibacterial drug development | Staphylococcus aureus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611, mixed-type inhibition against FabI with respect to the substrate trans-2-octenoyl N-acetylcysteamine and NADPH, prevents the growth of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with minimum inhibitory concentration of 0.016-0.032 mg/ml, overview | Staphylococcus aureus |  |
| degalactosylated aquastatin A | a natural inhibitor from the fungus Sporothrix sp. strain FN611 | Staphylococcus aureus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | activity measurement by reduction of the trans-2-octenoyl N-acetylcysteamine as substrate and NADPH as cofactor | Staphylococcus aureus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| enoyl-ACP reductase | - |
Staphylococcus aureus |
| enoyl-acyl carrier protein reductase | - |
Staphylococcus aureus |
| FabI | - |
Staphylococcus aureus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Staphylococcus aureus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Staphylococcus aureus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Staphylococcus aureus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0014 | - |
aquastatin A | pH 6.5, 30°C, versus NADPH | Staphylococcus aureus | |
| 0.00161 | - |
aquastatin A | pH 6.5, 30°C, versus trans-2-octenoyl N-acetylcysteamine | Staphylococcus aureus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0032 | - |
FabI, pH 6.5, 30°C | Staphylococcus aureus | aquastatin A | |
| 0.0034 | - |
FabI, pH 6.5, 30°C | Staphylococcus aureus | degalactosylated aquastatin A | |
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Release 2023.1 (January 2023)
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