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Literature summary for 1.3.1.14 extracted from

  • Kawasaki, S.; Satoh, T.; Todoroki, M.; Niimura, Y.
    b-Type dihydroorotate dehydrogenase is purified as a H2O2-forming NADH oxidase from Bifidobacterium bifidum (2009), Appl. Environ. Microbiol., 75, 629-636.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.14

Inhibitors

Inhibitors Comment Organism Structure
Hg2+ complete inhibition of both orotate reductase and NADH oxidase reaction Bifidobacterium bifidum
KCN complete inhibition of orotate reductase reaction Bifidobacterium bifidum
p-chloromercuribenzoate complete inhibition of both orotate reductase and NADH oxidase reaction Bifidobacterium bifidum
Quinacrine 19.2% inhibition of orotate reductase reaction Bifidobacterium bifidum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
 gel filtration Bifidobacterium bifidum

Organism

Organism UniProt Comment Textmining
Bifidobacterium bifidum B7X933 subunit PyrDb; bifunctional orotate reductase and H2O2-forming NADH oxidase
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bifidobacterium bifidum

Subunits

Subunits Comment Organism
tetramer 2 * subunit PyrDb plus 2 * subunit PyrK Bifidobacterium bifidum

Synonyms

Synonyms Comment Organism
b-type dihydroorotate dehydrogenase
-
 Bifidobacterium bifidum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 and 7.5, NADH oxidase reaction Bifidobacterium bifidum
7.5
-
 and 6.5, NADH oxidase reaction and dihydrorotate oxidase reaction Bifidobacterium bifidum

pH Range

pH Minimum pH Maximum Comment Organism
6.5
-
 70% of maximal activity, dihydrorotate oxidase reaction Bifidobacterium bifidum

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Bifidobacterium bifidum
FMN
-
 Bifidobacterium bifidum