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Literature summary for 1.3.1.2 extracted from

  • Haaz, M.C.; Fischel, J.L.; Formento, P.; Renee, N.; Etienne, M.C.; Milano, G.
    Impact of different fluorouracil biochemical modulators on cellular dihydropyrimidine dehydrogenase (1996), Cancer Chemother. Pharmacol., 38, 52-58.
    View publication on PubMed
Search for more literature for 1.3.1.2

Activating Compound

Activating Compound Comment Organism Structure
allopurinol cell lines CAL 27, CAL 51, ORL 1, PANC 3 Homo sapiens
cisplatin cell line ORL 1 Homo sapiens

Application

Application Comment Organism
medicine target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cisplatin cell lines CAL 27, CAL 33, CAL 51, PANC 3 Homo sapiens
dipyridamole cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism Homo sapiens
Hydroxyurea cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-fluorouracil + NADPH + H+ Homo sapiens
-
 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAL-27 cell
-
 Homo sapiens
-
CAL-33 cell
-
 Homo sapiens
-
CAL-51 cell
-
 Homo sapiens
-
carcinoma cell cancer cell line ORL 1 Homo sapiens
-
PANC-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + NADPH + H+
-
 Homo sapiens 5-fluoro-5,6-dihydrouracil + NADP+
-
 ?