Application | Comment | Organism |
---|---|---|
medicine | rate limiting enzyme for detoxification of exogenous fluoropyrimidines, antitumor drug design | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ | abstraction of pro-S hydrogen of NADPH and thus B-side stereospecific class dehydrogenase | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
uracil + NADPH | - |
Sus scrofa | 5,6-dihydrouracil + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | strictly dependent on | Sus scrofa |