Literature summary for 1.3.1.2 extracted from

van Kuilenburg, A.B.; Meijer, J.; Dobritzsch, D.; Lohkamp, B.; Ruitenbeek, W.; Roelofsen, J.; Abeling, N.G.; Duran, M.; Buzing, C.
Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria (2008), Nucleosides Nucleotides Nucleic Acids, 27, 809-815.

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Protein Variants

Protein Variants	Comment	Organism
R235Q	the mutation is expected to weaken the binding of the FAD ring system and to change the electronic environment and hence, the redox potential of the cofactor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thymine + NADPH + H+	-	Homo sapiens	5,6-dihydrothymine + NADP+	-	?
uracil + NADPH + H+	-	Homo sapiens	5,6-dihydrouracil + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
dihydropyrimidine dehydrogenase	-	Homo sapiens
DPD	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens

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Release 2023.1 (January 2023)