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Literature summary for 1.3.1.20 extracted from
- Dimeric dihydrodiol dehydrogenase in monkey kidney. Substrate specificity, stereospecificity of hydrogen transfer, and distribution (1989), J. Biochem., 106, 1104-1109.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.17 | - |
Camphorquinone | - |
Macaca fuscata |  |
| 2.6 | - |
trans-benzene dihydrodiol | - |
Macaca fuscata | |
| 2.7 | - |
Naphthalene dihydrodiol | - |
Macaca fuscata | |
| 3.3 | - |
4-nitrobenzaldehyde | - |
Macaca fuscata | |
| 5 | - |
dihydroxyacetone phosphate | - |
Macaca fuscata | |
| 5.4 | - |
dihydroxyacetone | - |
Macaca fuscata | |
| 45 | - |
D-glyceraldehyde | - |
Macaca fuscata | |
| 50 | - |
DL-glyceraldehyde-3-phosphate | - |
Macaca fuscata | |
| 121 | - |
L-glyceraldehyde | - |
Macaca fuscata | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
2 * 39000, SDS-PAGE | Macaca fuscata |
| 78000 | - |
- |
Macaca fuscata |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| naphthalene dihydrodiol + NAD(P)+ | Macaca fuscata | - |
? | - |
? | |
| trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | Macaca fascicularis | - |
catechol + NAD(P)H | - |
? | |
| trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | Macaca fuscata | - |
catechol + NAD(P)H | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca fascicularis | - |
crab-eating monkey | - |
| Macaca fuscata | - |
japanese monkey | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Macaca fuscata |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | proximal and distal tubules of the cortex, loop of Henle of the medulla | Macaca fascicularis | - |
| kidney | proximal and distal tubules of the cortex, loop of Henle of the medulla | Macaca fuscata | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Macaca fuscata |
| 0.11 | 0.12 | pH 10.0, kidney cortex, substrate trans-benzene dihydrodiol | Macaca fuscata |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3alpha-hydroxy steroid + NADP+ | - |
Macaca fuscata | 3-keto steroid + NADPH | - |
? | |
| 4-nitrobenzaldehyde + NAD(P)H | - |
Macaca fuscata | 4-nitrobenzylalcohol + NAD(P)+ | - |
? | |
| camphorquinone + NAD(P)H | - |
Macaca fuscata | (1R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+ | - |
? | |
| cis-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | not: | Macaca fuscata | catechol + NAD(P)H | - |
? | |
| D-glyceraldehyde + NADPH | - |
Macaca fuscata | ? | - |
? | |
| dihydroxyacetone + NADPH | - |
Macaca fuscata | ? | - |
? | |
| dihydroxyacetone phosphate + NADPH | - |
Macaca fuscata | ? | - |
? | |
| DL-glyceraldehyde-3-phosphate + NADPH | - |
Macaca fuscata | ? | - |
? | |
| L-glyceraldehyde + NADPH | - |
Macaca fuscata | ? | - |
? | |
| additional information | the enzyme transfers the 4-pro-R-hydrogen atom of NADPH to the carbonyl substrate | Macaca fuscata | additional information | - |
? | |
| naphthalene dihydrodiol + NAD(P)+ | - |
Macaca fuscata | ? | - |
? | |
| trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Macaca fascicularis | catechol + NAD(P)H | - |
? | |
| trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Macaca fuscata | catechol + NAD(P)H | - |
? | |
| trans-naphthalene dihydrodiol + NAD(P)+ | - |
Macaca fuscata | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 39000, SDS-PAGE | Macaca fuscata |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Macaca fascicularis |
| 25 | - |
assay at | Macaca fuscata |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.3 | - |
dihydroxyacetone phosphate | - |
Macaca fuscata | |
| 5.5 | - |
dihydroxyacetone | - |
Macaca fuscata | |
| 8 | - |
DL-glyceraldehyde-3-phosphate | - |
Macaca fuscata | |
| 9.1 | - |
L-glyceraldehyde | - |
Macaca fuscata | |
| 11.3 | - |
4-nitrobenzaldehyde | - |
Macaca fuscata | |
| 14 | - |
trans-benzene dihydrodiol | - |
Macaca fuscata | |
| 31.4 | - |
D-glyceraldehyde | - |
Macaca fuscata | |
| 34 | - |
trans-naphthalene dihydrodiol | - |
Macaca fuscata | |
| 62.5 | - |
Camphorquinone | - |
Macaca fuscata | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
reduction of alpha-diketones | Macaca fuscata |
| 9.8 | - |
trans-benzene dihydrodiol | Macaca fuscata |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Macaca fascicularis | |
| NADP+ | - |
Macaca fuscata | |
| NADPH | - |
Macaca fuscata | |
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