Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) | inhibits DD1 and DD3, inhibition can be overcome by androsterone for DD1 and by benzenedihydrodiol for DD3, not vice versa | Bos taurus | |
5alpha-androstan-3,17-dione | DD3 | Bos taurus | |
5beta-androstan-3,17-dione | DD3 | Bos taurus | |
5beta-Androstan-3alpha-ol-17-one | DD3 | Bos taurus | |
androsterone | DD3 | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0029 | - |
5beta-androstan-3,17-dione | DD1 | Bos taurus | |
0.0031 | - |
5alpha-androstan-3,17-dione | DD1 | Bos taurus | |
0.0048 | - |
androsterone | DD1 | Bos taurus | |
0.0074 | - |
5beta-Androstan-3alpha-ol-17-one | DD1 | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
immunologically cross-reactive isoforms DD1 and DD3 | - |
Purification (Comment) | Organism |
---|---|
DD1 and DD3 | Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ | isoform DD1 is identical with 3alpha-hydroxysteroid dehydrogenase EC 1.1.1.50, while isoform DD3 is a unique benzene dihydrodiol-specific enzyme | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha-hydroxy steroid + NADP+ | not, DD3 | Bos taurus | 3-keto steroid + NADPH | - |
? | |
5alpha-androstan-3,17-dione + NADPH | isoform DD1, identical with 3alpha-hydroxysteroid dehydrogenase EC 1.1.1.50 | Bos taurus | 5alpha-androstan-3alpha-ol-17-one + NADP+ | - |
? | |
5beta-androstan-3,17-dione + NADPH | - |
Bos taurus | 5beta-androstan-3alpha-ol-17-one + NADP+ | - |
? | |
androsterone + NADPH | DD1, identical with 3alpha-hydroxysteroid dehydrogenase EC 1.1.1.50 | Bos taurus | ? | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | DD3: specific for, no activity towards other alcohols, aldehydes, ketones and quinones | Bos taurus | catechol + NAD(P)H | - |
? | |
trans-naphthalene dihydrodiol + NAD(P)+ | - |
Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DD | - |
Bos taurus |
dihydrodiol dehydrogenase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
androsterone | DD3 | Bos taurus | |
0.011 | - |
5alpha-androstan-3,17-dione | DD3 | Bos taurus | |
0.031 | - |
5beta-Androstan-3alpha-ol-17-one | DD3 | Bos taurus | |
0.041 | - |
5beta-androstan-3,17-dione | DD3 | Bos taurus |