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Literature summary for 1.3.1.21 extracted from

  • Dempsey, M.E.
    Pathways of enzymic synthesis and conversion to cholesterol of DELTA-5,7,24-cholestatrien-3beta-ol and other naturally occurring sterols (1965), J. Biol. Chem., 240, 4176-4188.
    View publication on PubMed
Search for more literature for 1.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
1-[p-(beta-Diethylaminoethoxy) phenyl]1-(p-tolyl)-2-(p-chlorophenyl)ethanol i.e. MER-29 or triparanol Rattus norvegicus
trans-1,4-Bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride i.e. AY-9944, hypercholesterolaemic drug Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol 105000 x g fraction supernatant Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH Rattus norvegicus cholesterol biosynthesis cholesterol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3-beta-ol + NADPH cholesterol biosynthesis Rattus norvegicus cholesterol + NADP+
-
 ?
cholesta-5,7-dien-3beta-ol + NADPH
-
 Rattus norvegicus cholesterol + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus