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Literature summary for 1.3.1.21 extracted from

  • Anbalagan, M.; Yashwanth, R.; Jagannadha Rao, A.
    DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis (2004), Mol. Cell. Endocrinol., 219, 37-45.
    View publication on PubMed

Application

Application Comment Organism
diagnostics enzyme is a key marker of early Leydig cell steroidogenesis, using the technique of differential display RT-PCR Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
analysis of differentially expressed transcripts of gene dhcr7 in progenitor Leydig cells and in immature Leydig cells, increased expression of the enzyme during differentiation process Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information analysis of physiological effects of immunoneutralization of the enzyme in Leydig cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesta-5,7-dien-3beta-ol + NADPH Rattus norvegicus
-
cholesterol + NADP+
-
?
additional information Rattus norvegicus enzyme is essential for steroidogenesis, enzyme is not regulated by the luteinizing hormone LH ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Leydig cell progenitor cells, immature cells, and adult cells, differentially expressed transcripts and enzyme expression levels during development and differentiation, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesta-5,7-dien-3beta-ol + NADPH
-
Rattus norvegicus cholesterol + NADP+
-
?
cholesta-5,7-dien-3beta-ol + NADPH i.e. 7-dehydrocholesterol Rattus norvegicus cholesterol + NADP+
-
?
additional information enzyme is essential for steroidogenesis, enzyme is not regulated by the luteinizing hormone LH Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
Dhcr7
-
Rattus norvegicus