Activating Compound | Comment | Organism | Structure |
---|---|---|---|
sterol regulatory element | two sterol regulatory elements that bind sterol regulatory element-binding protein-2 work in cooperation to synergistically activate the enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3beta-ol + NADPH + H+ | Homo sapiens | - |
cholesterol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesta-5,7-dien-3beta-ol + NADPH + H+ | - |
Homo sapiens | cholesterol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dhcr7 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme absence leads to the devastating fetal developmental disorder Smith-Lemli-Opitz syndrome | Homo sapiens |
metabolism | the enzyme catalyzes the final step of cholesterol synthesis via the Kandutsch-Russell pathway, and is crucial in maintaining cellular cholesterol levels | Homo sapiens |