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Literature summary for 1.3.1.21 extracted from

  • Genaro-Mattos, T.C.; Allen, L.B.; Anderson, A.; Tallman, K.A.; Porter, N.A.; Korade, Z.; Mirnics, K.
    Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment (2019), Mol. Psychiatry, 24, 491-500 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in a time-pregnant mouse model where wild-type and Dhcr7+/- embryos are maternally exposed to aripiprazole or vehicle, aripiprazole and its metabolites are transported across the placenta and reach the brain of offspring. Maternal aripiprazole exposure leads to decreased viability of embryos and increased 7-DHC levels, regardless of maternal or offspring Dhcr7 genotype. Dhcr7+/- pups are more vulnerable to maternal aripiprazole exposure than their wild-type littermates, and maternal Dhcr7+/- genotype also exacerbates offspring response to aripiprazole treatment. Both 7-DHC levels and 7-DHC/cholesterol ratio is the highest in Dhcr7+/- pups from Dhcr7+/- mothers exposed to aripiprazole Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O88455
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Mus musculus
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