Literature summary for 1.3.1.22 extracted from

Holt, D.A.; Levy, M.A.; Ladd, D.L.; Oh, H.J.; Erb, J.M.; Heaslip, J.I.; Brandt, M.; Metcalf, B.M.
Steroidal A ring aryl carboxylic acids: a new class of steroid 5alpha-reductase inhibitors (1990), J. Med. Chem., 33, 937-942.

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Inhibitors

Inhibitors	Comment	Organism	Structure
17beta-Carbamoyl-1,3,5(10)-estratriene-3-carboxylic acids	formation of enzyme-NADP+-inhibitor complex	Homo sapiens
17beta-Carbamoyl-1,3,5(10)-estratriene-3-carboxylic acids	formation of enzyme-NADP+-inhibitor complex	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
a 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-DELTA4-steroid + NADPH + H+	mechanism	Homo sapiens	a
a 3-oxo-5alpha-steroid + NADP+ = a 3-oxo-DELTA4-steroid + NADPH + H+	mechanism	Rattus norvegicus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate gland	-	Homo sapiens	-
prostate gland	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
progesterone + NADPH + H+	-	Homo sapiens	5alpha-pregnan-3-20-dione + NADP+	-	?
progesterone + NADPH + H+	-	Rattus norvegicus	5alpha-pregnan-3-20-dione + NADP+	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens
NADPH	-	Rattus norvegicus

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Release 2023.1 (January 2023)