Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-ketoprogesterone | complete inhibition | Rattus norvegicus | |
17beta-hydroxyandrosta-1,4-dien-3-one | 50% inhibition | Rattus norvegicus | |
19-norandrost-4-ene-3,17-dione | complete inhibition | Rattus norvegicus | |
19-nortestosterone | complete inhibition | Rattus norvegicus | |
5alpha-androstane-3,17-dione | 30% inhibition | Rattus norvegicus | |
6alpha-methyl-11-ketoprogesterone | 25% inhibition | Rattus norvegicus | |
6beta-methyl-11-ketoprogesterone | 50% inhibition | Rattus norvegicus | |
androst-1-ene-3,17dione | 55% inhibition | Rattus norvegicus | |
androst-4-ene-3,17-dione | complete inhibition | Rattus norvegicus | |
progesterone | complete inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.14 | - |
cortisone | - |
Rattus norvegicus | |
0.53 | - |
NADPH | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha,21-dihydroxypregn-4-ene-3,11,20-trione + NADPH | trivial name cortisone | Rattus norvegicus | 17alpha,21-dihydroxy-5alpha-pregnan-3,11,20-trione + NADP+ | - |
ir | |
17alpha,21-dihydroxypregn-4-ene-3,20-dione + NADPH | - |
Rattus norvegicus | 17alpha,21-dihydroxy-5alpha-pregnane-3,20-dione | - |
? | |
17beta-methyl-androsta-4,9-dien-3-one + NADPH | - |
Rattus norvegicus | 17beta-methyl-5alpha-androst-9-en-3-one + NADP+ | - |
? | |
21-hydroxypregn-4-ene-3,20-dione + NADPH | - |
Rattus norvegicus | 21-hydroxy-5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Rattus norvegicus | androstan-3alpha,17beta-diol + androstan-3beta,17beta-diol + 5alpha-dihydrotestosterone | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 7.5 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.146 | - |
17beta-hydroxyandrosta-1,4-diene-3-one | - |
Rattus norvegicus |