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Literature summary for 1.3.1.22 extracted from
- Structure-function studies of human 5alpha-reductase type 2 using site directed mutagenesis (2001), J. Steroid Biochem. Mol. Biol., 77, 167-175.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| finasteride | replacement of residues 26-29 (AVFA) from isozyme 1 with residues 21-24 (GALA) from isozyme 2 increases the resistance to finasteride, what confirms that residues 26-29 from isozyme 1 are involved in the inhibitor/substrate binding but suggest residues 21-29 from isozyme 2 are not. More findings indicate that residues 15-17 of human 5 alpha-reductase 2 participate in inhibitor/substrate binding | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
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Release 2023.1 (January 2023)
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