Literature summary for 1.3.1.22 extracted from

Sz�csi, M.; Ondr�, D.; T�th, I.; Magony, S.; W�lfling, J.; Schneider, G.; Julesz, J.
Determination of rat 5alpha-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines (2010), Acta Biol. Hung., 61, 274-281.

Search for more literature for 1.3.1.22

Application

Application	Comment	Organism
analysis	radiosubstrate in vitro incubation method for the determination of 5alpha-reductase type 1 activity using rat liver microsomes as an enzyme source	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(5'S)-17beta-(2-chlorophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one	-	Rattus norvegicus
(5'S)-17beta-(4-bromophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one	-	Rattus norvegicus
finasteride	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	type 1 enzyme	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000008	-	pH 7.3, 37°C	Rattus norvegicus	finasteride
0.00072	-	pH 7.3, 37°C	Rattus norvegicus	(5'S)-17beta-(2-chlorophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one
0.00105	-	pH 7.3, 37°C	Rattus norvegicus	(5'S)-17beta-(4-bromophenyl-4,5-dihydrooxazol-5-yl)androst-5-en-3-one

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)