Literature summary for 1.3.1.22 extracted from

Gillespie, C.; Almli, L.; Smith, A.; Bradley, B.; Kerley, K.; Crain, D.; Mercer, K.; Weiss, T.; Phifer, J.; Tang, Y.; Cubells, J.; Binder, E.; Conneely, K.; Ressler, K.
Sex dependent influence of a functional polymorphism in steroid 5-alpha-reductase type 2 (SRD5A2) on post-traumatic stress symptoms (2013), Am. J. Med. Genet. B Neuropsychiatr. Genet., 162, 283-292.

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Application

Application	Comment	Organism
medicine	functional variation within isoform SRD5A2 influences, in a sex-specific way, the severity of post-traumatic stress symptoms and risk for diagnosis of post-traumatic stress disorder. There is a significant sex-dependent effect of genotype for the V89L variant in male but not female subjects on symptoms	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
V89L	a significant sex-dependent effect of genotype for the V89L variant in male but not female subjects on symptoms of post-traumatic stress disorder	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31213	isoform 5alpha-SR2	-

Synonyms

Synonyms	Comment	Organism
5alpha-SR2	-	Homo sapiens
SRD5A2	-	Homo sapiens

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Release 2023.1 (January 2023)