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Literature summary for 1.3.1.22 extracted from

  • Lin, S.F.; Lin, Y.H.; Lin, M.; Kao, Y.F.; Wang, R.W.; Teng, L.W.; Chuang, S.H.; Chang, J.M.; Yuan, T.T.; Fu, K.C.; Huang, K.P.; Lee, Y.S.; Chiang, C.C.; Yang, S.C.; Lai, C.L.; Liao, C.B.; Chen, P.; Lin, Y.S.; Lai, K.T.; Huang, H.J.; Yang, J.Y.; Liu, C.W.; Wei, W.Y.; Chen, C.K.; Hiipakka, R.A.; Liao, S.; Huang, J.J.
    Synthesis and structure-activity relationship of 3-O-acylated (-)-epigallocatechins as 5?-reductase inhibitors (2010), Eur. J. Med. Chem., 45, 6068-6076.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(2E,4E,6E,8E)-((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate compound shows moderate anti-tumour activity in vivo Rattus norvegicus
(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl palmitoate activity of 3-O-acylated (e)-epigallocatechins increases with the increasing carbon numbers of the fatty acid moiety, reaching maximum for palmitoate Rattus norvegicus
(Z)-((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl) hexadec-9-enoate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00048
-
 pH not specified in the publication, temperature not specified in the publication Rattus norvegicus (Z)-((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl) hexadec-9-enoate
0.00053
-
 pH not specified in the publication, temperature not specified in the publication Rattus norvegicus (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl palmitoate
0.00076
-
 pH not specified in the publication, temperature not specified in the publication Rattus norvegicus (2E,4E,6E,8E)-((2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetraenoate