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Literature summary for 1.3.1.24 extracted from
- Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt (2009), J. Biol. Chem., 284, 21369-21378.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the vector pcDNA3.1 | Mus musculus |
| into the vector pcDNA3.1 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E47A | mutant, does affect the edge of the beta2 strand of substrate and cofactor binding in the pocket, which likely influences the strength of their interaction with BVR | Mus musculus |
| E97A | mutant, data strongly support this site as important for conversion of biliverdin to bilirubin and for transmission of signaling by BVR | Mus musculus |
| Y198F | mutant, phosphorylation site | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| siRNA | - |
Homo sapiens | |
| siRNA | - |
Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | external plasma membrane | Mus musculus | 5886 | - |
| plasma membrane | external plasma membrane | Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + NADP+ | Mus musculus | - |
biliverdin + NADPH + H+ | - |
r |  |
| bilirubin + NADP+ | Homo sapiens | - |
biliverdin + NADPH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Mus musculus |
| phosphoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| macrophage | - |
Mus musculus | - |
| RAW-264.7 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + NADP+ | - |
Mus musculus | biliverdin + NADPH + H+ | - |
r | |
| bilirubin + NADP+ | - |
Homo sapiens | biliverdin + NADPH + H+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| biliverdin reductase A | - |
Mus musculus |
| biliverdin reductase A | - |
Homo sapiens |
| BVR | - |
Mus musculus |
| BVR | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
| NADPH | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | bacterial endotoxin, lipopolysaccharide, initiates an inflammatory response in macrophages coming along with a rapid increase in BVR surface expression | up |
| Homo sapiens | bacterial endotoxin, lipopolysaccharide, initiates an inflammatory response in macrophages coming along with a rapid increase in BVR surface expression | up |
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Release 2023.1 (January 2023)
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