Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.3 extracted from

  • McNeilly, A.D.; Macfarlane, D.P.; OFlaherty, E.; Livingstone, D.E.; Mitic, T.; McConnell, K.M.; McKenzie, S.M.; Davies, E.; Reynolds, R.M.; Thiesson, H.C.; Skott, O.; Walker, B.R.; Andrew, R.
    Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice (2010), J. Hepatol., 52, 705-711.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.1.3

Application

Application Comment Organism
medicine role for bile acids in inhibiting hepatic glucocorticoid clearance, of sufficient magnitude to suppress hypothalamic-pituitary-adrenal axis activity. Elevated hepatic bile acids may account for adrenal insufficiency in liver disease Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
chenodeoxycholic acid competitively inhibits 5beta-reductase Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0092
-
 chenodeoxycholic acid pH not specified in the publication, temperature not specified in the publication Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus presence of chenodeoxycholic acid reduces transcript abundance in H4iiE cell and promoter activity in HepG2 cells down