Literature summary for 1.3.1.43 extracted from

Mayer, E.; Waldner-Sander, S.; Keller, B.; Keller, E.; Lingens, F.
Purification of arogenate dehydrogenase from Phenylobacterium immobile (1985), FEBS Lett., 179, 208-212.

Search for more literature for 1.3.1.43

Inhibitors

Inhibitors	Comment	Organism	Structure
prephenate	competitive inhibition	Phenylobacterium immobile

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.02	-	NAD+	-	Phenylobacterium immobile
0.09	-	L-arogenate	-	Phenylobacterium immobile

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
38400	-	2 * 38400, SDS-PAGE	Phenylobacterium immobile
69000	-	gel electrophoresis after cross-linking with dimethylsuberimidate	Phenylobacterium immobile

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-arogenate + NAD+	Phenylobacterium immobile	i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine	L-tyrosine + NADH + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Phenylobacterium immobile	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Phenylobacterium immobile

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Phenylobacterium immobile
95.5	-	-	Phenylobacterium immobile

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-arogenate + NAD(P)+	i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine	Phenylobacterium immobile	L-tyrosine + NAD(P)H + CO2	-	?
L-arogenate + NAD+	i.e. 3-(1-carboxy-4-hydroxycyclohexa-2,5-dien-1-yl)-L-alanine, final biosynthetic step to tyrosine	Phenylobacterium immobile	L-tyrosine + NADH + CO2	-	?
additional information	highly specific for arogenate	Phenylobacterium immobile	?	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 38400, SDS-PAGE	Phenylobacterium immobile

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
9.5	-	-	Phenylobacterium immobile

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Phenylobacterium immobile

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Release 2023.1 (January 2023)