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Literature summary for 1.3.1.6 extracted from

  • Chen, M.; Zhai, L.; Christensen, S.B.; Theander, T.G.; Kharazmi, A.
    Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones (2001), Antimicrob. Agents Chemother., 45, 2023-2029.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine might serve as target for anti-Leishmania drugs Leishmania donovani
medicine might serve as target for anti-Leishmania drugs Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
2,4-dimethoxy-4'-allyloxychalcone
-
Leishmania donovani
2,4-dimethoxy-4'-allyloxychalcone
-
Leishmania major
2,4-dimethoxy-4'-butoxychalcone
-
Leishmania donovani
2,4-dimethoxy-4'-butoxychalcone
-
Leishmania major
lipochalcone A
-
Leishmania donovani
lipochalcone A
-
Leishmania major
succinate
-
Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumarate + NADH + H+ Leishmania donovani
-
succinate + NAD+
-
?
fumarate + NADH + H+ Leishmania major
-
succinate + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-
Leishmania major
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Leishmania donovani

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumarate + NADH + H+
-
Leishmania donovani succinate + NAD+
-
?
fumarate + NADH + H+
-
Leishmania major succinate + NAD+
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Leishmania donovani
NADH
-
Leishmania major