Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.6 extracted from

  • Chen, M.; Bennedsen, M.; Zhai, L.; Kharazmi, A.
    Purification and enzymatic activity of an NADH-fumarate reductase and other mitochondrial activities of Leishmania parasites (2001), APMIS, 109, 801-808.
    View publication on PubMed

Application

Application Comment Organism
medicine might serve as target for anti-Leishmania drugs Leishmania donovani
medicine might serve as target for anti-Leishmania drugs Leishmania major

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
Leishmania donovani
Cu2+
-
Leishmania major
malonate
-
Leishmania donovani
Zn2+ strong inhibitor Leishmania donovani
Zn2+ strong inhibitor Leishmania major

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Leishmania donovani 16020
-
mitochondrion
-
Leishmania major 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
65000
-
-
Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumarate + NADH + H+ Leishmania donovani component of respiratory chain succinate + NAD+
-
?
fumarate + NADH + H+ Leishmania major component of respiratory chain succinate + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-
Leishmania major
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Leishmania donovani

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
Leishmania donovani
-
promastigote
-
Leishmania donovani
-
promastigote
-
Leishmania major
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2189
-
purified enzyme from promastigotes Leishmania donovani

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumarate + NADH + H+
-
Leishmania donovani succinate + NAD+
-
?
fumarate + NADH + H+
-
Leishmania major succinate + NAD+
-
?
fumarate + NADH + H+ component of respiratory chain Leishmania donovani succinate + NAD+
-
?
fumarate + NADH + H+ component of respiratory chain Leishmania major succinate + NAD+
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Leishmania donovani
NADH
-
Leishmania major