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Literature summary for 1.3.1.6 extracted from

  • Vieites, M.; Smircich, P.; Parajon-Costa, B.; Rodriguez, J.; Galaz, V.; Olea-Azar, C.; Otero, L.; Aguirre, G.; Cerecetto, H.; Gonzalez, M.; Gomez-Barrio, A.; Garat, B.; Gambino, D.
    Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase (2008), J. Biol. Inorg. Chem., 13, 723-735.
    View publication on PubMed

Application

Application Comment Organism
drug development lack of NADH-fumarate reductase in mammalian cells provides an interesting target against Chagas disease Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
Pd-(pyridine-2-thiol N-oxide)2 inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, marked increase is obeserved in the inhibitory effect with respect to that of the free ligand, inhibition in a dose-dependent manner, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate Trypanosoma cruzi
Pt-(pyridine-2-thiol N-oxide)2 inhibitory effect of metal-pyridine-2-thiol N-oxide complexes, inhibition observed 2 is similar to that obtained with the ligand alone, a clear relief of the growth inhibition produced by the metal-mpo complex is observed in the presence of 5 mM succinate Trypanosoma cruzi
pyridine-2-thiol N-oxide 2-mercaptopyridine N-oxide (mpo) is a bioactive ligand with a potential as antitrypanosomal agent Trypanosoma cruzi
sodium pyridine-2-thiol N-oxide inhibitory effect of the sodium salt Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fumarate + NADH + H+ Trypanosoma cruzi parasite-specific enzyme, succinate is one of the main respiratory substrates and is therefore required by the parasite for energy production succinate + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epimastigote
-
Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fumarate + NADH + H+ parasite-specific enzyme, succinate is one of the main respiratory substrates and is therefore required by the parasite for energy production Trypanosoma cruzi succinate + NAD+
-
?

Synonyms

Synonyms Comment Organism
NADH-fumarate reductase
-
Trypanosoma cruzi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Trypanosoma cruzi