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Literature summary for 1.3.1.6 extracted from

  • Tomitsuka, E.; Kita, K.; Esumi, H.
    The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments (2010), Ann. N. Y. Acad. Sci., 1201, 44-49.
    View publication on PubMed
Search for more literature for 1.3.1.6

Application

Application Comment Organism
medicine the enzyme is a target in anticancer therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pyrvinium pamoate an anthelmintic drug, has an anticancer effect within tumor-mimicking microenvironments, biological mechanism of pyrvinium is the inhibition of the NADH-fumarate reductase system. Under normal conditions, pyrvinium pamoate activates complex II activity and inhibits complex I activity. Pyrvinium pamoate activates the mitochondrial respiratory chain via complex II, despite inhibiting complex I. In cancer cells under hypoxic and glucose-deprived conditions, the activation of SQR by pyrvinium pamoate disappeared and NADH-fumarate reductase activity is inhibited. Pyrvinium pamoate becomes cytotoxic to cancer cells under tumor microenvironmental conditions Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinate + NAD+ Homo sapiens
-
 fumarate + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + NAD+
-
 Homo sapiens fumarate + NADH + H+
-
 r

Synonyms

Synonyms Comment Organism
NADH-FR
-
 Homo sapiens
NADH-fumarate reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens
NADH
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is part of the NADH-fumarate reductase system in cancer cell microenvironments, with deficiencies of critical nutrients and hypoxia, where it is important for maintaining mitochondrial energy metabolism, overview. The NADH-fumarate reductase system is the function of complex II Homo sapiens