Cloned (Comment) | Organism |
---|---|
- |
Neurospora crassa |
Protein Variants | Comment | Organism |
---|---|---|
D207N | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D227N | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D276N | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D289E | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D289N | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D293N | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D394N | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D462N | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
D463N | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
E22Q | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
E233D | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
E233Q | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
E475Q | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
H388A | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
H457A | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
K229A | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
K351A | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
K351R | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
K469A | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R212A | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R217A | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R235A | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R235K | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R345A | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R355A | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R458A | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R458K | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R461A | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
R461K | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
T371A | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y124F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y273F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y391F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y445F | site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y447F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y470F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y477F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Y490F | site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a | Neurospora crassa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
A25822B | competitive inhibitor | Neurospora crassa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Neurospora crassa | enzyme plays a key role in sterol biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neurospora crassa | - |
gene erg-3, strain 74-OR23-1 mat, and enzyme-deficient mutant strains OR8-1 mat a and erg-3 mat a | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+ | determination of residues critical for activity, overview | Neurospora crassa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mycelium | - |
Neurospora crassa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme plays a key role in sterol biosynthesis | Neurospora crassa | ? | - |
? | |
additional information | the charge and geometry given via residues E233, R235, D289, K351, R458, and R461 is important for enzyme activity | Neurospora crassa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sterol C-14 reductase | - |
Neurospora crassa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Neurospora crassa |