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Literature summary for 1.3.1.76 extracted from

  • Raux, E.; McVeigh, T.; Peters, S.E.; Leustek, T.; Warren, M.J.
    The role of Saccharomyces cerevisiae MET1p and MET8p in sirohaem and cobalamin biosynthesis (1999), Biochem. J., 338, 701-708.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
MET8 mutants complemented by Salmonella typhimurium cysG, cloned and expressed in Escherichia coli Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
precorrin-2 + NAD+ Saccharomyces cerevisiae siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III sirohydrochlorin + NADH + H+
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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yeast
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Purification (Commentary)

Purification (Comment) Organism
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Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
precorrin-2 + NAD+
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Saccharomyces cerevisiae sirohydrochlorin + NADH + H+
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?
precorrin-2 + NAD+ siroheme and cobalamin biosynthesis, second of three steps leading to formation of siroheme from uroporphyrinogen III Saccharomyces cerevisiae sirohydrochlorin + NADH + H+
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?

Synonyms

Synonyms Comment Organism
cobaltochelatase
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Saccharomyces cerevisiae
Met8p
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Saccharomyces cerevisiae