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Literature summary for 1.3.1.8 extracted from

  • Mizugaki, M.; Uchiyama, M.
    Possible role of NADPH-dependent enoyl coenzyme A reductase in -oxidation of unsaturated fatty acids (1973), Biochem. Biophys. Res. Commun., 50, 48-53.
    View publication on PubMed
Search for more literature for 1.3.1.8

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide
-
 Rattus norvegicus
N-ethylmaleimide
-
 Rattus norvegicus
p-chloromercuribenzoate
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2
-
 2-cis-octenoyl-CoA
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus role in beta-oxidation of fatty acids ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 no information in the literature concerning reduction of cis-2-enoyl-CoA substrates, thus classification of rat enzyme according to EC 1.3.1.8 or EC 1.3.1.38 impossible
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-cis-octenoyl-CoA + NADPH
-
 Rattus norvegicus octanoyl-CoA + NADP+
-
 ?
2-trans-octenoyl-CoA + NAD(P)H trans isomer exhibits 1/3 of activity of cis isomer Rattus norvegicus octanoyl-CoA + NADP+
-
 ?
additional information role in beta-oxidation of fatty acids Rattus norvegicus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8.5
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH inactive with NADH Rattus norvegicus