Literature summary for 1.3.1.9 extracted from

Karioti, A.; Skaltsa, H.; Zhang, X.; Tonge, P.J.; Perozzo, R.; Kaiser, M.; Franzblau, S.G.; Tasdemir, D.
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata (2008), Phytomedicine, 15, 1125-1129.

Search for more literature for 1.3.1.9

Inhibitors

Inhibitors	Comment	Organism	Structure
4-acetoxyanthecotulide	moderate inhibition	Plasmodium falciparum
4-hydroxyanthecotulide	moderate inhibition	Plasmodium falciparum
anthecotulide	-	Mycobacterium tuberculosis
anthecotulide	moderate inhibition	Plasmodium falciparum
additional information	not inhibited by anthecotulide, 4-hydroxyanthecotulide, and 4-acetoxyanthecotulide	Escherichia coli
additional information	not inhibited by 4-hydroxyanthecotulide and 4-acetoxyanthecotulide	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	strain ATCC 35218	-
Mycobacterium tuberculosis	-	-	-
Mycobacterium tuberculosis H37Rv	-	-	-
Plasmodium falciparum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
crotonyl-CoA + NADH + H+	-	Escherichia coli	butyryl-CoA + NAD+	-	?
crotonyl-CoA + NADH + H+	-	Mycobacterium tuberculosis	butyryl-CoA + NAD+	-	?
crotonyl-CoA + NADH + H+	-	Plasmodium falciparum	butyryl-CoA + NAD+	-	?
crotonyl-CoA + NADH + H+	-	Mycobacterium tuberculosis H37Rv	butyryl-CoA + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
enoyl-ACP reductase	-	Escherichia coli
enoyl-ACP reductase	-	Mycobacterium tuberculosis
enoyl-ACP reductase	-	Plasmodium falciparum
FabI	-	Escherichia coli
FabI	-	Mycobacterium tuberculosis
FabI	-	Plasmodium falciparum

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Escherichia coli
NADH	-	Mycobacterium tuberculosis
NADH	-	Plasmodium falciparum

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Release 2023.1 (January 2023)