Application | Comment | Organism |
---|---|---|
medicine | targeting enoyl-ACP reductase is a viable approach to new antimicrobial agents | Bacillus anthracis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[4-(2-hydroxy-4-propylphenoxy)phenyl]ethanone | - |
Bacillus anthracis | |
2-(2,4-dinitrophenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(2-chloro-4-nitrophenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(3-dimethylaminophenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(3-hydroxymethyl-phenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(3-nitrophenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(4-aminophenoxy)-5-chlorophenol | - |
Bacillus anthracis | |
2-(4-aminophenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(4-methanesulfinylphenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(4-methanesulfonylphenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(4-methylsulfanylphenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(4-nitrophenoxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(biphenyl-3-yloxy)-5-propylphenol | - |
Bacillus anthracis | |
2-(biphenyl-4-yloxy)-5-chlorophenol | - |
Bacillus anthracis | |
2-phenoxy-5-propylphenol | - |
Bacillus anthracis | |
2-[3-(2-hydroxy-4-chlorophenoxy)phenoxy]-5-chlorophenol | - |
Bacillus anthracis | |
2-[3-(2-hydroxy-4-propylphenoxy)phenoxy]-5-propylphenol | - |
Bacillus anthracis | |
2-[3-(2-hydroxy-ethyl)phenoxy]-5-propylphenol | - |
Bacillus anthracis | |
2-[4-(1-hydroxyethyl)phenoxy]-5-propylphenol | - |
Bacillus anthracis | |
2-[4-(2-hydroxy-4-chlorophenoxy)phenoxy]-5-chlorophenol | - |
Bacillus anthracis | |
2-[4-(2-hydroxy-4-propylphenoxy)phenoxy]-5-propylphenol | - |
Bacillus anthracis | |
3-(2-hydroxy-4-propylphenoxy)benzoic acid | - |
Bacillus anthracis | |
3-(2-hydroxy-4-propylphenoxy)benzoic acid methylester | - |
Bacillus anthracis | |
3-(3-hydroxy-4-phenoxyphenyl)propane-1,2-diol | - |
Bacillus anthracis | |
3-chloro-4-(2-hydroxy-4-propylphenoxy)benzamide | - |
Bacillus anthracis | |
3-chloro-4-(2-hydroxy-4-propylphenoxy)benzonitrile | - |
Bacillus anthracis | |
3-[3-(2-hydroxy-4-propylphenoxy)phenyl]acrylic acid methylester | - |
Bacillus anthracis | |
3-[3-(2-hydroxy-4-propylphenoxy)phenyl]propionic acid | - |
Bacillus anthracis | |
3-[3-(2-hydroxy-4-propylphenoxy)phenyl]propionic acid methylester | - |
Bacillus anthracis | |
3-[5-chloro-2-(2,4-dichlorophenoxy)phenoxy]pyridine | - |
Bacillus anthracis | |
4-(4-chloro-2-hydroxyphenoxy)-1-(4-methylphenylsulphonamido)benzene | - |
Bacillus anthracis | |
4-phenoxybenzene-1,3-diol | - |
Bacillus anthracis | |
5-(benzylaminomethyl)-2-phenoxyphenol | - |
Bacillus anthracis | |
5-chloro-2-(2-chloro-4-nitrophenoxy)phenol | - |
Bacillus anthracis | |
5-chloro-2-(2-nitrophenoxy)phenol | - |
Bacillus anthracis | |
5-chloro-2-(4-hydroxyphenoxy)phenol | - |
Bacillus anthracis | |
5-chloro-2-(4-nitrophenoxy)phenol | - |
Bacillus anthracis | |
5-chloro-2-phenoxyaniline | - |
Bacillus anthracis | |
5-chloro-2-phenoxyphenol | - |
Bacillus anthracis | |
5-chloro-2-phenoxyphenylmethanol | - |
Bacillus anthracis | |
5-hydroxymethyl-2-phenoxyphenol | - |
Bacillus anthracis | |
5-nitro-2-phenoxyphenol | - |
Bacillus anthracis | |
5-propyl-2-(3-trifluoromethylphenoxy)phenol | - |
Bacillus anthracis | |
isoniazid | - |
Bacillus anthracis | |
N-[4-(4-chloro-2-hydroxyphenoxy)phenyl]acetamide | - |
Bacillus anthracis | |
triclosan | - |
Bacillus anthracis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus anthracis | A0A348A0U3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
crotonyl-CoA + NAD+ | activity assay | Bacillus anthracis | butyryl-CoA + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BaENR | - |
Bacillus anthracis |
enoyl-ACP reductase | - |
Bacillus anthracis |
ENR | - |
Bacillus anthracis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
activity assay | Bacillus anthracis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Bacillus anthracis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
0.5% inhibition at 1 microM | Bacillus anthracis | 3-[5-chloro-2-(2,4-dichlorophenoxy)phenoxy]pyridine | |
additional information | - |
1.6% inhibition at 1 microM | Bacillus anthracis | N-[4-(4-chloro-2-hydroxyphenoxy)phenyl]acetamide | |
additional information | - |
1.8% inhibition at 1 microM | Bacillus anthracis | 5-chloro-2-phenoxyphenylmethanol | |
additional information | - |
10.0% inhibition at 1 microM | Bacillus anthracis | 2-[4-(2-hydroxy-4-propylphenoxy)phenoxy]-5-propylphenol | |
additional information | - |
12.6% inhibition at 1 microM | Bacillus anthracis | 2-(3-dimethylaminophenoxy)-5-propylphenol | |
additional information | - |
15.5% inhibition at 1 microM | Bacillus anthracis | 2-[4-(2-hydroxy-4-chlorophenoxy)phenoxy]-5-chlorophenol | |
additional information | - |
17.1% inhibition at 1 microM | Bacillus anthracis | 2-[4-(1-hydroxyethyl)phenoxy]-5-propylphenol | |
additional information | - |
17.6% inhibition at 1 microM | Bacillus anthracis | 3-[3-(2-hydroxy-4-propylphenoxy)phenyl]propionic acid | |
additional information | - |
17.9% inhibition at 1 microM | Bacillus anthracis | 3-[3-(2-hydroxy-4-propylphenoxy)phenyl]propionic acid | |
additional information | - |
2.6% inhibition at 1 microM | Bacillus anthracis | 5-chloro-2-(4-hydroxyphenoxy)phenol | |
additional information | - |
20.6% inhibition at 1 microM | Bacillus anthracis | 2-[3-(2-hydroxy-4-propylphenoxy)phenoxy]-5-propylphenol | |
additional information | - |
4.4% inhibition at 1 microM | Bacillus anthracis | 5-chloro-2-phenoxyaniline | |
additional information | - |
5.0% inhibition at 1 microM | Bacillus anthracis | 5-hydroxymethyl-2-phenoxyphenol | |
additional information | - |
7.2% inhibition at 1 microM | Bacillus anthracis | 5-chloro-2-(4-nitrophenoxy)phenol | |
additional information | - |
7.9% inhibition at 1 microM | Bacillus anthracis | 5-(benzylaminomethyl)-2-phenoxyphenol | |
additional information | - |
9.2% inhibition at 1 microM | Bacillus anthracis | 3-(2-hydroxy-4-propylphenoxy)benzoic acid | |
additional information | - |
9.8% inhibition at 1 microM | Bacillus anthracis | 3-(3-hydroxy-4-phenoxyphenyl)propane-1,2-diol | |
additional information | - |
9.9% inhibition at 1 microM | Bacillus anthracis | 2-[3-(2-hydroxy-4-chlorophenoxy)phenoxy]-5-chlorophenol | |
0.0003 | - |
- |
Bacillus anthracis | 5-chloro-2-(2-chloro-4-nitrophenoxy)phenol | |
0.0005 | - |
- |
Bacillus anthracis | 5-chloro-2-phenoxyphenol | |
0.0005 | - |
- |
Bacillus anthracis | 2-(2-chloro-4-nitrophenoxy)-5-propylphenol | |
0.0005 | - |
- |
Bacillus anthracis | 2-(biphenyl-3-yloxy)-5-propylphenol | |
0.0006 | - |
- |
Bacillus anthracis | triclosan | |
0.0006 | - |
- |
Bacillus anthracis | 2-(4-methylsulfanylphenoxy)-5-propylphenol | |
0.0008 | - |
- |
Bacillus anthracis | 1-[4-(2-hydroxy-4-propylphenoxy)phenyl]ethanone | |
0.0008 | - |
larger than 0.0008 mM | Bacillus anthracis | 2-phenoxy-5-propylphenol | |
0.0008 | - |
larger than 0.008 mM | Bacillus anthracis | 3-chloro-4-(2-hydroxy-4-propylphenoxy)benzonitrile | |
0.0011 | - |
- |
Bacillus anthracis | 2-(4-nitrophenoxy)-5-propylphenol | |
0.0011 | - |
- |
Bacillus anthracis | 3-chloro-4-(2-hydroxy-4-propylphenoxy)benzamide | |
0.00124 | - |
- |
Bacillus anthracis | 5-propyl-2-(3-trifluoromethylphenoxy)phenol | |
0.002 | - |
- |
Bacillus anthracis | 3-(2-hydroxy-4-propylphenoxy)benzoic acid methylester | |
0.0022 | - |
- |
Bacillus anthracis | 2-(4-methanesulfonylphenoxy)-5-propylphenol | |
0.0036 | - |
- |
Bacillus anthracis | 2-(2,4-dinitrophenoxy)-5-propylphenol | |
0.0036 | - |
- |
Bacillus anthracis | 2-(4-methanesulfinylphenoxy)-5-propylphenol | |
0.006 | - |
- |
Bacillus anthracis | 2-[3-(2-hydroxy-ethyl)phenoxy]-5-propylphenol | |
0.00625 | - |
larger than 0.00625 mM | Bacillus anthracis | 2-(biphenyl-4-yloxy)-5-chlorophenol | |
0.00625 | - |
larger than 0.00625 mM | Bacillus anthracis | 3-[3-(2-hydroxy-4-propylphenoxy)phenyl]acrylic acid methylester | |
0.0063 | - |
- |
Bacillus anthracis | 4-phenoxybenzene-1,3-diol | |
0.0071 | - |
- |
Bacillus anthracis | 2-(4-aminophenoxy)-5-chlorophenol | |
0.0075 | - |
- |
Bacillus anthracis | 3-[3-(2-hydroxy-4-propylphenoxy)phenyl]propionic acid methylester | |
0.0077 | - |
- |
Bacillus anthracis | 5-chloro-2-(2-nitrophenoxy)phenol | |
0.008 | - |
larger than 0.008 mM | Bacillus anthracis | 2-(3-nitrophenoxy)-5-propylphenol | |
0.0088 | - |
- |
Bacillus anthracis | 2-(4-aminophenoxy)-5-propylphenol | |
0.012 | - |
larger than 0.012 mM | Bacillus anthracis | 4-(4-chloro-2-hydroxyphenoxy)-1-(4-methylphenylsulphonamido)benzene | |
0.0203 | - |
- |
Bacillus anthracis | 2-(3-hydroxymethyl-phenoxy)-5-propylphenol | |
0.05 | - |
larger than 0.050 mM | Bacillus anthracis | 5-nitro-2-phenoxyphenol |