Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.9 extracted from

  • Banerjee, T.; Sharma, S.K.; Kapoor, N.; Dwivedi, V.; Surolia, N.; Surolia, A.
    Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase (2011), IUBMB Life, 63, 1101-1110.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide competitive kinetics with cofactor NADH and uncompetitive kinetics with the substrate crotonyl-CoA Plasmodium falciparum
3-bromo-N-[4-(trifluoromethyl)benzyl]-1-benzothiophene-2-carboxamide competitive kinetics with cofactor NADH and uncompetitive kinetics with the substrate crotonyl-CoA Plasmodium falciparum
triclosan
-
Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
crotonyl-CoA + NADH + H+
-
Plasmodium falciparum butyryl-CoA + NAD+
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000018
-
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide substrate NADH, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.000091
-
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide substrate crotonyl-CoA, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000089
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum triclosan
0.000115
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide
0.000463
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 3-bromo-N-[4-(trifluoromethyl)benzyl]-1-benzothiophene-2-carboxamide