Application | Comment | Organism |
---|---|---|
medicine | upregulation of hDUS2 is a relatively common feature of pulmonary carcinogenesis. Selective suppression of hDUS2 enzyme activity and/or inhibition of formation of the hDUS2-tRNA synthetase complex could be a promising therapeutic strategy for treatment of many lung cancers. Significant association between higher levels of hDUS2 in tumors and poorer prognosis of lung cancer patients | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NX74 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
non-small cell lung adenocarcinoma cell line | overexpression of hDUS2 in nonsmall cell lung carcinomas is identified by analysis of the gene-expression profiles | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
hDUS2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | upregulation of hDUS2 is a relatively common feature of pulmonary carcinogenesis | up |
General Information | Comment | Organism |
---|---|---|
malfunction | a small interfering RNA against hDUS2 transfected into NSCLC cells suppresses expression of the gene, reduces the amount of dihydrouridine in tRNA molecules, and suppresses growth | Homo sapiens |