Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.91 extracted from

  • Kato, T.; Daigo, Y.; Hayama, S.; Ishikawa, N.; Yamabuki, T.; Ito, T.; Miyamoto, M.; Kondo, S.; Nakamura, Y.
    A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis (2005), Cancer Res., 65, 5638-5646.
    View publication on PubMed

Application

Application Comment Organism
medicine upregulation of hDUS2 is a relatively common feature of pulmonary carcinogenesis. Selective suppression of hDUS2 enzyme activity and/or inhibition of formation of the hDUS2-tRNA synthetase complex could be a promising therapeutic strategy for treatment of many lung cancers. Significant association between higher levels of hDUS2 in tumors and poorer prognosis of lung cancer patients Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NX74
-
-

Source Tissue

Source Tissue Comment Organism Textmining
non-small cell lung adenocarcinoma cell line overexpression of hDUS2 in non–small cell lung carcinomas is identified by analysis of the gene-expression profiles Homo sapiens
-

Synonyms

Synonyms Comment Organism
hDUS2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens upregulation of hDUS2 is a relatively common feature of pulmonary carcinogenesis up

General Information

General Information Comment Organism
malfunction a small interfering RNA against hDUS2 transfected into NSCLC cells suppresses expression of the gene, reduces the amount of dihydrouridine in tRNA molecules, and suppresses growth Homo sapiens