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Literature summary for 1.3.1.93 extracted from

  • Paul, S.; Gable, K.; Dunn, T.
    A six-membrane-spanning topology for yeast and Arabidopsis Tsc13p, the enoyl reductases of the microsomal fatty acid elongating system (2007), J. Biol. Chem., 282, 19237-19246.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
D77A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
E144A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
E259A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
E91A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
H137A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
H149A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
K140A mutant is not able to complement an enzyme deletion mutant. Mutant protein is present at wild-type levels and does not show altered membrane topology Saccharomyces cerevisiae
K76A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
R141A mutant is not able to complement an enzyme deletion mutant. Mutant protein is present at wild-type levels and does not show altered membrane topology Saccharomyces cerevisiae
Y103A mutation is not critical for function, mutant is able to complement an enzyme deletion mutant Saccharomyces cerevisiae
Y138A mutant is not able to complement an enzyme deletion mutant, protein is unstable Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome presence of six putative membrane-spanning domains Arabidopsis thaliana
-
-
microsome the N and C termini of the enzyme reside in the cytoplasm, and six putative membrane-spanning domains have been identified. The N-terminal domain including the first membrane-spanning segment contains sufficient information for targeting to the endoplasmic reticulum membrane Saccharomyces cerevisiae
-
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9M2U2
-
-
Saccharomyces cerevisiae Q99190
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein the native glycosylation sites at residues 38 and 255 of the enzyme are not modified Saccharomyces cerevisiae
no glycoprotein the native glycosylation sites at residues N76 and N244 of the enzyme are not modified Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
TSC13
-
 Arabidopsis thaliana