Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | A77 1726, active metabolite of leflumonide | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant protein | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroorotate + acceptor | - |
Homo sapiens | orotate + reduced acceptor | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | 0.0009 | 2-hydroxyethylidene-cyanoacetic acid 4-trifluoromethyl anilide | competitive to ubiquinone, non-competitive to dihydroorotate, parent compound leflunomide has no inhibitory effect at concentrations up to 0.001 mM | Homo sapiens |