Literature summary for 1.3.5.2 extracted from

Baumgartner, R.; Walloschek, M.; Kralik, M.; Gotschlich, A.; Tasler, S.; Mies, J.; Leban, J.
Dual binding mode of a novel series of DHODH inhibitors (2006), J. Med. Chem., 49, 1239-1247.

Search for more literature for 1.3.5.2

Application

Application	Comment	Organism
medicine	development of small molecule inhibitors against DHODH	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with low molecular weight compounds that inhibit the enzyme in the nanomolar range, by hanging-drop vapor diffusion method, to 2.15 A resolution	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	competitive nature of small molecule inhibitors toward the putative ubiquinone binding site	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q02127	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydroorotate + 2,6-dichlorophenolindophenol	-	Homo sapiens	orotate + reduced 2,6-dichlorophenolindophenol	-	?

Synonyms

Synonyms	Comment	Organism
DHODH	-	Homo sapiens

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Release 2023.1 (January 2023)