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Literature summary for 1.3.8.8 extracted from

  • Ikeda, Y.; Hine, D.G.; Okamura-Ikeda, K.; Tanaka, K.
    Mechanism of action of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases. Direct evidence for carbanion formation as an intermediate step using enzyme-catalyzed C-2 proton/deuteron exchange in the absence of C-3 exchange (1985), J. Biol. Chem., 260, 1326-1337.
    View publication on PubMed
Search for more literature for 1.3.8.8

Inhibitors

Inhibitors Comment Organism Structure
HgCl2 inhibition of enzyme-catalyzed C-2 proton-deuteron exchange reactions Rattus norvegicus
Methylmercury iodide inhibition of enzyme-catalyzed C-2 proton-deuteron exchange reactions Rattus norvegicus
p-chloromercuribenzoate inhibition of enzyme-catalyzed C-2 proton-deuteron exchange reactions Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme-catalyzed proton-deuteron exchange experiments in absence of an electron acceptor, deuterium atom replaces hydrogen from C-2 giving experimental evidence for the initial C-2 proton abstraction Rattus norvegicus ?
-
 ?
palmitoyl-CoA + electron-transfer flavoprotein
-
 Rattus norvegicus 2-hexadecenoyl-CoA + reduced electron-transfer flavoprotein
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.5
-
 palmitoyl-CoA enzyme-catalyzed C-2 proton-deuteron exchange reaction Rattus norvegicus
5.4
-
 palmitoyl-CoA
-
 Rattus norvegicus